We are a married couple in our mid-30's and are not usually cruisers, but booked this mainly for the destinations. Overall the cruise went well, despite a minor bout of food sickness. Embarkation went very smoothly, although it was quite a walk to get from the train to the ship in Venice. Disembarkation went smoothly as well; we opted to carry our own luggage and pretty much walked right off the boat and then took a cab to our hotel. We had an ocean view cabin which was spacious and in great condition. Service was overall very good, and the entertainment was OK despite the fact that they really put in a lot of effort to try and put on a great show. Food was just OK - there was no significant difference between the dining room and buffet food, and we did experience minor food sickness during the cruise. It did pass in a day or so, and the overall cruise rating would have been higher if it wasn't for this incident.
Ports - booked excursions for half of the ports and mostly through the ship; the only one that we could find a better deal through a 3rd party was for the one in Istanbul.
-Venice - took the Alilaguna to our hotel near St Mark's/Doge Palace (~15 Eur/ea). Rialto, Santa Maria, and all other main sites are easily accessible by walking or Vaporetto water taxi. Venice is a little overwhelming at first due to language and the tiny streets, but it gets better after you get your bearings straight and realize how to catch the water taxis in the right direction.