Find Cruises to the Panama Canal & Central America

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Showing results 1630 of 131 cruises
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20 Nights Panama Passage
Departure Port: Charleston
Sailing Dates
2018 Jan 3
Crystal Cruises
Crystal Serenity
Pro: Out-of-this-world service, fabulous enrichment activities, inclusive fares
Con: Can feel clubby with older, repeat passengers and formal atmosphere
Bottom Line: You'll be pampered but never bored on luxury's largest ship
Day 1 Charleston
Day 2 Charleston
Day 3 Fort Lauderdale (Port Everglades)
Day 4 Key West
Day 5 Caribbean Sea (Cruising)
Day 6 Caribbean Sea (Cruising)
Day 7 Cartagena (Colombia)
Day 8 Caribbean Sea (Cruising)
Day 9 Panama Canal
Day 9 Panama City
Day 10 Panama City
Day 11 Cruising
Day 12 Puntarenas (Puerto Caldera)
Day 13 Cruising
Day 14 Cruising
Day 15 Acapulco
Day 16 Cruising
Day 17 Puerto Vallarta
Day 18 Cabo San Lucas
Day 19 Cruising
Day 20 San Diego
Day 21 Los Angeles
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18 Nights Panama Passage
Departure Port: Fort Lauderdale (Port Everglades)
Sailing Dates
2018 Jan 5
Crystal Cruises
Crystal Serenity
Pro: Out-of-this-world service, fabulous enrichment activities, inclusive fares
Con: Can feel clubby with older, repeat passengers and formal atmosphere
Bottom Line: You'll be pampered but never bored on luxury's largest ship
Day 1 Fort Lauderdale (Port Everglades)
Day 2 Key West
Day 3 Caribbean Sea (Cruising)
Day 4 Caribbean Sea (Cruising)
Day 5 Cartagena (Colombia)
Day 6 Caribbean Sea (Cruising)
Day 7 Panama Canal
Day 8 Panama City
Day 9 Cruising
Day 10 Puntarenas (Puerto Caldera)
Day 11 Cruising
Day 12 Cruising
Day 13 Acapulco
Day 15 Puerto Vallarta
Day 16 Cabo San Lucas
Day 17 Cruising
Day 18 San Diego
Day 19 Los Angeles
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18 Nights Panama Adventure
Departure Port: Fort Lauderdale (Port Everglades)
Sailing Dates
2018 Apr 30
Crystal Cruises
Crystal Symphony
Pro: Superb service and cuisine
Con: Production shows need improvement
Bottom Line: A luxurious experience with big-ship amenities
Day 1 Fort Lauderdale (Port Everglades)
Day 2 Caribbean Sea (Cruising)
Day 3 Grand Cayman
Day 4 Caribbean Sea (Cruising)
Day 5 Cartagena (Colombia)
Day 6 Gatun Lake
Day 7 Cruising
Day 8 San Juan del Sur
Day 9 Cruising
Day 10 Puerto Quetzal (Antigua)
Day 11 Cruising
Day 12 Huatulco
Day 13 Cruising
Day 14 Puerto Vallarta
Day 15 Cabo San Lucas
Day 16 Cruising
Day 17 San Diego
Day 18 San Diego
Day 19 Los Angeles
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8 Nights West Coast Wayfarer
Departure Port: San Francisco
Sailing Dates
2019 Jun 17
Crystal Cruises
Crystal Symphony
Pro: Superb service and cuisine
Con: Production shows need improvement
Bottom Line: A luxurious experience with big-ship amenities
Day 1 San Francisco
Day 2 San Francisco
Day 3 Monterey
Day 4 U.S. East Coast
Day 5 Astoria
Day 6 Seattle
Day 7 Victoria
Day 8 Vancouver
Day 9 Vancouver
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20 Nights Grand Panama Canal
Departure Port: San Francisco
Sailing Dates
2018 Aug 10
Crystal Cruises
Crystal Symphony
Pro: Superb service and cuisine
Con: Production shows need improvement
Bottom Line: A luxurious experience with big-ship amenities
Day 1 San Francisco
Day 2 U.S. East Coast
Day 3 Cruising
Day 4 Cabo San Lucas
Day 5 Cruising
Day 6 Cruising
Day 7 Puerto Chiapas
Day 8 Puerto Quetzal (Antigua)
Day 9 San Juan del Sur
Day 10 Puntarenas (Puerto Caldera)
Day 11 Cruising
Day 12 Gatun Lake
Day 13 Cartagena (Colombia)
Day 14 Caribbean Sea (Cruising)
Day 15 Caribbean Sea (Cruising)
Day 16 Bimini
Day 17 Atlantic Ocean (Cruising)
Day 18 Charleston
Day 19 U.S. East Coast
Day 20 New York (Manhattan)
Day 21 New York (Manhattan)
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29 Night Transcanal Cruise
Departure Port: Southampton
Sailing Dates
2018 Jan 7
Cunard Line
Queen Elizabeth
Elegant with plenty of opportunities for formal dressing
Varied enrichment program
Sense of occasion on every cruise
Beautiful public spaces
Superb art and memorabilia collection
Some of the most luxurious suites at sea
Day 1 Southampton
Day 2 Cruising
Day 3 Cruising
Day 4 Cruising
Day 5 Cruising
Day 6 Cruising
Day 7 Cruising
Day 8 Hamilton
Day 9 Cruising
Day 10 New York (Manhattan)
Day 11 New York (Manhattan)
Day 12 Cruising
Day 13 Cruising
Day 14 Fort Lauderdale (Port Everglades)
Day 15 Cruising
Day 16 Ocho Rios
Day 17 Cruising
Day 18 Aruba
Day 19 Cruising
Day 20 Panama Canal
Day 21 Cruising
Day 22 Cruising
Day 23 Puerto Quetzal (Antigua)
Day 24 Cruising
Day 25 Cruising
Day 26 Cabo San Lucas
Day 27 Cruising
Day 28 Cruising
Day 29 San Francisco
Day 30 San Francisco
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19 Night Transcanal Cruise
Departure Port: New York (Manhattan)
Sailing Dates
2018 Jan 17
Cunard Line
Queen Elizabeth
Elegant with plenty of opportunities for formal dressing
Varied enrichment program
Sense of occasion on every cruise
Beautiful public spaces
Superb art and memorabilia collection
Some of the most luxurious suites at sea
Day 1 New York (Manhattan)
Day 2 Cruising
Day 3 Cruising
Day 4 Fort Lauderdale (Port Everglades)
Day 5 Cruising
Day 6 Ocho Rios
Day 7 Cruising
Day 8 Aruba
Day 9 Cruising
Day 10 Panama Canal
Day 11 Cruising
Day 12 Cruising
Day 13 Puerto Quetzal (Antigua)
Day 14 Cruising
Day 15 Cruising
Day 16 Cabo San Lucas
Day 17 Cruising
Day 18 Cruising
Day 19 San Francisco
Day 20 San Francisco
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16 Night Transcanal Cruise
Departure Port: Fort Lauderdale (Port Everglades)
Sailing Dates
2018 Jan 20
Cunard Line
Queen Elizabeth
Elegant with plenty of opportunities for formal dressing
Varied enrichment program
Sense of occasion on every cruise
Beautiful public spaces
Superb art and memorabilia collection
Some of the most luxurious suites at sea
Day 1 Fort Lauderdale (Port Everglades)
Day 2 Cruising
Day 3 Ocho Rios
Day 4 Cruising
Day 5 Aruba
Day 6 Cruising
Day 7 Panama Canal
Day 8 Cruising
Day 9 Cruising
Day 10 Puerto Quetzal (Antigua)
Day 11 Cruising
Day 12 Cruising
Day 13 Cabo San Lucas
Day 14 Cruising
Day 15 Cruising
Day 16 San Francisco
Day 17 San Francisco
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27 Night Transcanal Cruise
Departure Port: Southampton
Sailing Dates
2019 Jan 10
Cunard Line
Queen Victoria
Pro: Stylish and sophisticated, offering world-wide itineraries
Con: Passengers who don't like to dress up will feel out of place
Bottom line: Queen Victoria is more traditional and formal than most ships, with an elegant atmosphere
Day 1 Southampton
Day 2 Cruising
Day 3 Cruising
Day 4 Cruising
Day 5 Cruising
Day 6 Cruising
Day 7 Cruising
Day 8 Hamilton
Day 9 Cruising
Day 10 Cruising
Day 11 Port Canaveral (Orlando)
Day 12 Fort Lauderdale (Port Everglades)
Day 13 Cruising
Day 14 Cruising
Day 15 Aruba
Day 16 Cruising
Day 17 Cartagena (Colombia)
Day 18 Panama Canal
Day 19 Cruising
Day 20 Puntarenas (Puerto Caldera)
Day 21 Cruising
Day 22 Cruising
Day 23 Cruising
Day 24 Cabo San Lucas
Day 25 Cruising
Day 26 Cruising
Day 27 San Francisco
Day 28 San Francisco
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16 Night Transcanal Cruise
Departure Port: Fort Lauderdale (Port Everglades)
Sailing Dates
2019 Jan 21
Cunard Line
Queen Victoria
Pro: Stylish and sophisticated, offering world-wide itineraries
Con: Passengers who don't like to dress up will feel out of place
Bottom line: Queen Victoria is more traditional and formal than most ships, with an elegant atmosphere
Day 1 Fort Lauderdale (Port Everglades)
Day 2 Cruising
Day 3 Cruising
Day 4 Aruba
Day 5 Cruising
Day 6 Cartagena (Colombia)
Day 7 Panama Canal
Day 8 Cruising
Day 9 Puntarenas (Puerto Caldera)
Day 10 Cruising
Day 11 Cruising
Day 12 Cruising
Day 13 Cabo San Lucas
Day 14 Cruising
Day 15 Cruising
Day 16 San Francisco
Day 17 San Francisco
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14-night Halloween On The High Seas Eastbound Panama Canal Cruise From San Diego To Galveston
Departure Port: San Diego
Sailing Dates
2017 Oct 27 More
2018 Oct 19 Less
Disney Cruise Line
Disney Wonder
Pros: Only ship in the fleet with "Frozen, a Musical Spectacular" and Tiana's Place restaurant
Cons: Most activities need to be booked in advance, leaving those who didn't out of luck
Bottom Line: Most notable for its unique kids club spaces, modern adult areas and Alaska itineraries
Day 1 San Diego
Day 2 Cruising
Day 3 Cabo San Lucas
Day 4 Puerto Vallarta
Day 5 Cruising
Day 6 Cruising
Day 7 Cruising
Day 8 Cruising
Day 9 Panama City
Day 10 Cartagena (Colombia)
Day 11 Cruising
Day 12 Grand Cayman
Day 13 Cozumel
Day 14 Cruising
Day 15 Galveston
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15-day Panama Canal Holiday
Departure Port: San Diego
Sailing Dates
2017 Dec 20
Holland America Line
Amsterdam
Pro: Fabulous entertainment, despite ship's small size
Con: Not much variety of dining
Bottom Line: Great value for bucket-list itineraries
Day 1 San Diego
Day 2 Cruising
Day 3 Cabo San Lucas
Day 4 Puerto Vallarta
Day 5 Cruising
Day 6 Cruising
Day 7 Puerto Quetzal (Antigua)
Day 8 Corinto
Day 9 Puntarenas (Puerto Caldera)
Day 10 Cruising
Day 11 Panama Canal (Cruising)
Day 11 Panama Canal
Day 11 Panama Canal
Day 12 Cartagena (Colombia)
Day 13 Cruising
Day 14 Cruising
Day 15 Half Moon Cay
Day 16 Fort Lauderdale (Port Everglades)
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17-day Panama Canal
Departure Port: Fort Lauderdale (Port Everglades)
Sailing Dates
2018 May 10
Holland America Line
Amsterdam
Pro: Fabulous entertainment, despite ship's small size
Con: Not much variety of dining
Bottom Line: Great value for bucket-list itineraries
Day 1 Fort Lauderdale (Port Everglades)
Day 2 Cruising
Day 3 Cruising
Day 4 Cartagena (Colombia)
Day 5 Panama Canal (Cruising)
Day 5 Panama Canal
Day 5 Panama Canal
Day 6 Cruising
Day 7 Corinto
Day 8 Puerto Quetzal (Antigua)
Day 9 Huatulco
Day 10 Cruising
Day 11 Cruising
Day 12 Cabo San Lucas
Day 13 Cruising
Day 14 Cruising
Day 15 San Francisco
Day 16 Cruising
Day 17 Victoria
Day 18 Seattle
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17-day Panama Canal
Departure Port: Fort Lauderdale (Port Everglades)
Sailing Dates
2018 Apr 18
Holland America Line
Eurodam
Pro: Exceptional dining and entertainment options
Con: Up-selling in spa and shops can feel a bit excessive
Bottom Line: Traditional ship with fresh, modern touches
Day 1 Fort Lauderdale (Port Everglades)
Day 2 Cruising
Day 3 Cruising
Day 4 Cartagena (Colombia)
Day 5 Panama Canal (Cruising)
Day 5 Panama Canal
Day 5 Panama Canal
Day 6 Cruising
Day 7 Puntarenas (Puerto Caldera)
Day 8 Corinto
Day 9 Puerto Quetzal (Antigua)
Day 10 Puerto Chiapas
Day 11 Huatulco
Day 12 Cruising
Day 13 Manzanillo
Day 14 Puerto Vallarta
Day 15 Cabo San Lucas
Day 16 Cruising
Day 17 Cruising
Day 18 San Francisco
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19-day Panama Canal
Departure Port: Vancouver
Sailing Dates
2017 Oct 17
Holland America Line
Eurodam
Pro: Exceptional dining and entertainment options
Con: Up-selling in spa and shops can feel a bit excessive
Bottom Line: Traditional ship with fresh, modern touches
Day 1 Vancouver
Day 2 Cruising
Day 3 Cruising
Day 4 San Francisco
Day 5 Cruising
Day 6 Cruising
Day 7 Cruising
Day 8 Puerto Vallarta
Day 9 Cruising
Day 10 Cruising
Day 11 Puerto Chiapas
Day 12 Puerto Quetzal (Antigua)
Day 13 Corinto
Day 14 Puntarenas (Puerto Caldera)
Day 15 Cruising
Day 16 Panama Canal (Cruising)
Day 16 Panama Canal
Day 16 Panama Canal
Day 17 Cartagena (Colombia)
Day 18 Cruising
Day 19 Cruising
Day 20 Fort Lauderdale (Port Everglades)
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