We took a Tauck river cruise from Prague to Budapest on the Swiss Jewel. While this is a review of that cruise, we have a special focus. Gale has limited mobility, and the majority of the off-boat tours were done with her in a transport chair pushed by her husband Bob.
The chair has a thick cushion, which was critical for comfort. It has 12" foam wheels in the rear and 6" removable wheels in front. It collapses easily, and was stored in the reception area of the boat. Gale was able to move easily throughout the boat using her Canadian crutch, and took advantage of the elevator to get to the lounge and dining area. She also had to walk on and-off the boat, since the gang-plank was too narrow and steep for the chair. Also, there were times when two or three boats were docked next to each other, and this required going through (or up and over) one or two boats. The busses also have 4-to-6 steps, and the seats are not so easy to get into and-out of.
That said, the trip was a wonderful experience, and the cobblestones the price of admission. Here is a non-typical tourist view. Our reviews of private time in Prague, the hotel, and two great restaurants (Imperial and Amade) are on TripAdvisor.