Located in a small, flat prairie valley and surrounded by 500-foot bluffs -- a surprise in the flat Midwest -- La Crosse was named by an explorer in 1805 after he spotted a group of Native Americans playing a sport with sticks he thought resembled the staff traditionally carried by the Bishop of Notre Dame. The city, which was settled some 35 years later, went on to become one of Wisconsin's largest centers for lumber and sawmills.
Today, the city, a stop on Upper Mississippi River cruises, offers visitors a mix of historic homes, scenic vistas and an intriguing blend of Scandinavian, German and Irish cultures. If you've got the legs for it, take a hike up Grandad Bluff, mentioned by Mark Twain in "Life on the Mississippi," where the view of the Mississippi valley below encompasses three states: Wisconsin, Minnesota and Iowa.