Yes, Transport Canada's ban on cruise activities will likely impact most major cruise sailings to Alaska in 2021. But several small ship lines, which generally have American-built ships and crew, and stay primarily within Alaska waters, can still sail in 2021.
Here is the list.
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UnCruise Adventures

Alaskan Dream Cruises

American Cruise Lines

Lindblad Expeditions

The Boat Company

Updated February 10, 2021
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