The sail in and out of the Bay Area is a visual treat. Do yourself a favor and be topside for sail into and out of port. The scenery and chances for quality photos are worth getting up early for. Spent two days and 1 night in port. San Francisco offers something for every palate. We did tours to Sonoma visiting 3 wineries and rode the Napa Wine Train on the second day. Both tours were worth the money and gave us a quality scouting run for our next trip.
Going to say a few words about Astoria Oregon here because it is not an option in the port review section. The city did a good job of welcoming us. There was plenty of transportation to shopping, merchants set up tents just outside the security barrier, the tour to wine country required a long bus ride but the winery was nice and lunch was wonderful, last but not least the local high school band sent the ship away with a few songs.
Seattle has sooooo much to do. We pulled in downtown at Pier 66, which is the better of the 2 cruise ship locations. Transportation at the port is plentiful. If you go into the city there are stairs/hills to negotiate. Took the tour to 2 wineries and got a few minutes to see the Public Market. Most of the grapes for the wineries are grown on the other side of the mountains in Eastern Washington. The Pinot was great and you must see the Market to believe it. The flowers were incredible and the tricks done with the fish at the Market were the icing on the cake.
City is wonderful and clean. The Butchart Gardens are a sight to behold and should not be missed if visiting. Took over 200 pictures and I am sure I missed some stuff. The Gardens provide a path for those with and without mobility issues and no one will feel cheated. Don't forget to visit the Harbor and the Fairmont Empress Hotel.