Stayed one night at Residence Candia: They did just fine. We weren't looking for luxory in a hotel since we didn't plan to be there much. We picked that hotel because of reasonable price and its location to the Vatican which we planned to go at 9 am the next day... (remember jet lag!)
Taxi from airport to Hotel: at that time the price for the taxi was same price as train... Economic times may have been hard with the slow economy in 2010. In hind site it is the way to go... we were in no mood for problems on a train/subway after the long flight. Just do the cab thing.
We crashed at the hotel and then struck out around 3 pm. Asked the hotel lady of a local place to eat lunch where locals go... she told us of a place.... a little bar type restaurant...it was just perfect!
We did the Double Bus thing to get us around for a bit... we where still tired. That worked for us...took us to key sites and allowed us to soak it all in.
Trevi Fountain in the Evening! Trevi was one of my all time favorites of the who trip... however going in the night made it just amazing. Can't describe it...just go at night if you can.
Collosium: Great. My son definately wanted to see it. We didn't get to go inside because of the lines...wish we did. We walked around it and some of the ruins but wish we had gone inside.... we also tried to return at night... to see it lit up.... subway station was shut down! ugh.
Pantheon: Really, really cool building.
Vatican/Cistean: naturally is a must. whatever you do get tickets on line! You don't want to wait in those hedious lines! It was a great time. By placing this early in the AM it worked nicely to get us to Civitiveccia to Embark the Cruise later that day.
In hind site: Rome is naturally a tremendous place. If you haven't been there certainly go. Be aware though, that if you are going to Venice and Florence they have similaritiest or Rome. Venice is now my #2 city...second only to Paris!