We took private transport with Roll Call group members to hotel in Rome and spend three nights there. Hotel as Albergo Cesari located exactly half way between Pantheon and Trevi Fountain and it was a really nice find. Nice room (small but bigger the cruise ship cabin) and great staff. Super rooftop terrace with bar and great morning breakfast. Highly recommend this hotel.
We saw all the main sights (St. Peter's, Vatican Museum, Colosseum, St, Ignatius de Loyola, Castel St. Angelo (nice cafe on top), Plaza Navona, Campo di Fiori, Spanish Steps, Trevi Fountain and much more.
Off the beaten path we greatly enjoyed taking bus to Pyramide metro stop and seeing the pyramid and touring the non-Catholic cemetery with graves of Shelly, Keats and Goethe as well as the cats roaming everywhere from the neighboring sanctuary. Then we took train to Ostia Antica and toured the ancient Roman seaport ruins. VERY worthwhile.
One wheelchair note - everywhere in Rome is paved with San Pietro Stone and is very difficult with wheelchair. I would say that for a solo wheelchair user it would be impossible and curb ramps are rare. Rome is perhaps the most wheelchair unfriendly city we have ever been in. Barcelona was by far the best.