I live in Baltimore, and sailing out of your home port is extremely civilized. The drop off procedure in the Baltimore port couldn't have been easier. If you have to park there it's too expensive ($15 a day). Not outrageous, but enough for us to find someone to just drop us off.
Make sure you're on top-deck when you sail under the key bridge. Not to be missed.
I was able to get 3G service on my iPhone until we crossed the bay bridge-tunnel, late that first night.
If you can book a rear-facing cabin, do it! Very big balcony with two chaise lounges and two chairs. Probably a 10x10 balcony.